CRS0540 Gram-positives

Preclinical program targeting antibiotic-resistant Gram-positive infections.

  • MRSA skin infections
  • MRSA & PRSP pneumonia
  • Group A strep
  • Group B strep and Listeria neonatal infections
  • VRE bacteremia
  • Anthrax
  • Listeria food poisoning




Ongoing Studies




News / Updates

CRS0540 Gram-positives Overview

We are developing a novel class of small molecule antibiotics targeting PolC, the replicative DNA polymerase in Gram-positive bacteria. By inhibiting a novel bacterial target, these compounds circumvent existing mechanisms of antibiotic resistance. CRS0540 exhibits broad spectrum activity against all clinically significant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), Streptococcus pyogenes (Group A strep), Streptococcus agalactiae (Group B strep), vancomycin-resistant Enterococci (VRE), Bacillus anthracis (anthrax), and Listeria monocytogenes.

Key Areas of Study

  • Novel mechanism of action based on inhibition of PolC, an essential DNA polymerase
  • Oral bioavailability, facilitating outpatient treatment
  • Bactericidal activity
  • Low spontaneous resistance rates
  • In vivo efficacy in preclinical models of infection
  • Low propensity for toxicity observed in vitro and in vivo

Ongoing CRS0540 Gram-positives Studies

Novel antibacterial candidate CRS0540 is still in pre-clinical development, so no clinical studies are available for this drug candidate at the moment. If you’d like to help further our research into novel antibacterial drugs, you may be interested in joining our phase 2 clinical study on CRS3123 for C. difficile. Another project in our pipeline, CRS3123 is a drug being developed to treat a devastating GI tract infection. Learn more about our ongoing clinical study below.

CRS0540 News / Updates

Become a Part of This Project

Interested in helping further our research into novel antibacterial agents? We’d be thrilled to have your help, either as an investor, a team member, or a participant in our ongoing clinical studies.


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Clinical Studies

Learn how you can become part of our ongoing clinical study to fight deadly GI tract infections.